abstract：:Amelogenins, the major protein components of the enamel extracellular matrix, are postulated to be involved in controlling the elongated and oriented growth of enamel carbonated apatite crystals. In order to clarify the functional role of amelogenin during the early stage of enamel biomineralization, octacalcium phosp...

journal_title：Calcified tissue international

authors： Iijima M,Moradian-Oldak J

更新日期：2004-06-01 00:00:00

abstract：:Bone is a dynamic tissue that is able to sense and adapt to mechanical stimuli by modulating its mass, geometry, and structure. Bone marrow stromal cells (BMSCs) are known to play an integral part in bone formation by providing an osteoprogenitor cell source capable of differentiating into mature osteoblasts in respon...

journal_title：Calcified tissue international

authors： Mauney JR,Sjostorm S,Blumberg J,Horan R,O'Leary JP,Vunjak-Novakovic G,Volloch V,Kaplan DL

更新日期：2004-05-01 00:00:00

abstract：:Several studies have shown an association between circulating leptin concentration and bone mineral density. but most studies are cross-sectional in design and report findings in women only. We per-formed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spi...

journal_title：Calcified tissue international

authors： Dennison EM,Syddall HE,Fall CH,Javaid MK,Arden NK,Phillips DI,Cooper C

更新日期：2004-05-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To clarify this mechanism, we investigated the effects o...

journal_title：Calcified tissue international

authors： Iwasaki K,Furukawa KI,Tanno M,Kusumi T,Ueyama K,Tanaka M,Kudo H,Toh S,Harata S,Motomura S

更新日期：2004-05-01 00:00:00

abstract：:Because of the variability of collagen crosslinks, their use as markers for bone resorption is often criticized. We hypothesized that the variability could be reduced by collecting urine for 24 hours (or longer) instead of using single voids, and by not normalizing to creatinine. Urine samples were collected from 22 h...

journal_title：Calcified tissue international

authors： Smith SM,Dillon EL,DeKerlegand DE,Davis-Street JE

更新日期：2004-04-01 00:00:00

abstract：:Bone injury occurs in human hemolytic disorders associated with thrombosis, such as beta-thalassemia and sickle cell disease. Exposure of rats to 2-butoxyethanol (BE) has been associated with hemolytic anemia, disseminated thrombosis, and infarction in multiple organs including bone. This rat model apparently mimics a...

journal_title：Calcified tissue international

authors： Shabat S,Nyska A,Long PH,Goelman G,Abramovitch R,Ezov N,Levin-Harrus T,Peddada S,Redlich M,Yedgar S,Nyska M

更新日期：2004-03-01 00:00:00

abstract：:We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...

journal_title：Calcified tissue international

authors： Rejnmark L,Jørgensen ME,Pedersen MB,Hansen JC,Heickendorff L,Lauridsen AL,Mulvad G,Siggaard C,Skjoldborg H,Sørensen TB,Pedersen EB,Mosekilde L

更新日期：2004-03-01 00:00:00

abstract：:In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid...

journal_title：Calcified tissue international

authors： García-Pérez MA,Moreno-Mercer J,Tarín JJ,Cano A

更新日期：2004-02-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

journal_title：Calcified tissue international

authors： Maran A,Hefferan TE,Zhang M,Turner RT

更新日期：2004-02-01 00:00:00

abstract：:To clarify the mechanisms underlying shockwave-induced osteogenesis, we applied shockwave to rat femoral shafts from the ventral side. We assessed bone mineral content (BMC) and bone mineral density (BMD), and analyzed the spatial and temporal gene expression for pro-alpha1 (I) collagen (COL1A1), pro-alpha1 (II) colla...

journal_title：Calcified tissue international

authors： Takahashi K,Yamazaki M,Saisu T,Nakajima A,Shimizu S,Mitsuhashi S,Moriya H

更新日期：2004-02-01 00:00:00

abstract：:The purpose of this study was to use the concept of metastable equilibrium solubility (MES) to describe the anomalous solubility behavior of carbonated apatite (CAP) in the presence of solution strontium. A CAP sample (4.8 wt% CO(3), synthesized at 70 degrees C) was prepared by precipitation. Baseline MES distribution...

journal_title：Calcified tissue international

authors： Heslop DD,Bi Y,Baig AA,Higuchi WI

更新日期：2004-01-01 00:00:00

abstract：:The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...

journal_title：Calcified tissue international

authors： Pinheiro MM,Castro CH,Frisoli A Jr,Szejnfeld VL

更新日期：2003-12-01 00:00:00

abstract：:Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...

journal_title：Calcified tissue international

authors： Chen E,Yuan ZA,Wright JT,Hong SP,Li Y,Collier PM,Hall B,D'Angelo M,Decker S,Piddington R,Abrams WR,Kulkarni AB,Gibson CW

更新日期：2003-11-01 00:00:00

abstract：:Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...

journal_title：Calcified tissue international

authors： Gartland A,Buckley KA,Bowler WB,Gallagher JA

更新日期：2003-10-01 00:00:00

abstract：:The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...

journal_title：Calcified tissue international

authors： Komarova SV,Shum JB,Paige LA,Sims SM,Dixon SJ

更新日期：2003-09-01 00:00:00

abstract：:The fossil record shows that bone remodeling has existed since the earliest large vertebrates became weight-bearing on land, but the functions of remodeling have long been debated. The principal protagonists in this debate have been those favoring a mechanical function and those asserting that remodeling serves to mov...

journal_title：Calcified tissue international

authors： Martin RB

更新日期：2003-08-01 00:00:00

abstract：:The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...

journal_title：Calcified tissue international

authors： Goto A,Tsukamoto I

更新日期：2003-08-01 00:00:00

abstract：:Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K1 supplementation on bone loss have been reported thus far. In the trial presented here we have in...

journal_title：Calcified tissue international

authors： Braam LA,Knapen MH,Geusens P,Brouns F,Hamulyák K,Gerichhausen MJ,Vermeer C

更新日期：2003-07-01 00:00:00

abstract：:The accompanying article by Drs. Lian and Stein describes current thinking on how genes are organized in the nucleus and suggests that subnuclear localization is critical for the control of gene expression in bone. In particular, it is proposed that a major function of the osteoblast transcription factor, Runx2, is to...

journal_title：Calcified tissue international

authors： Franceschi RT

更新日期：2003-06-01 00:00:00

abstract：:We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3 mg/kg/day, we found that SP500263 partially protected against OVX-induced loss of bone mineral content in the distal ends of femurs and in the who...

journal_title：Calcified tissue international

authors： Sutherland MK,Brady H,Gayo-Fung LM,Leisten J,Lipps SG,McKie JA,O'Leary E,Patnaik N,Anderson DW,Bhagwat SS,Stein B

更新日期：2003-06-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...

journal_title：Calcified tissue international

authors： Tong W,Glimcher MJ,Katz JL,Kuhn L,Eppell SJ

更新日期：2003-05-01 00:00:00

abstract：:The aim of this study was to evaluate the association among phalangeal morphometric parameters, amplitude-dependent speed of sound (AD-SOS), ultrasound bone profile index (UBPI), and spinal bone mineral density (BMD) and fracture status. One hundred women (controls, mean age 53 +/- 12 years) and 40 osteoporotic women ...

journal_title：Calcified tissue international

authors： Guglielmi G,Njeh CF,de Terlizzi F,De Serio DA,Scillitani A,Cammisa M,Fan B,Lu Y,Genant HK

更新日期：2003-04-01 00:00:00

abstract：:The purpose of this research was to address the following question: How is the solubility of fluoride-pretreated carbonated apatite (CAP) in aqueous acidic media related to the equilibrium solution fluoride and/or the CAP adsorbed fluoride levels? A CAP sample prepared by a precipitation method at 70 degrees C contain...

journal_title：Calcified tissue international

authors： Barry AB,Zhuang H,Baig AA,Higuchi WI

更新日期：2003-03-01 00:00:00

abstract：:Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to stu...

journal_title：Calcified tissue international

authors： Ciana G,Martini C,Leopaldi A,Tamaro G,Katouzian F,Ronfani L,Bembi B

更新日期：2003-03-01 00:00:00

abstract：:Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...

journal_title：Calcified tissue international

authors： Carden A,Rajachar RM,Morris MD,Kohn DH

更新日期：2003-02-01 00:00:00

abstract：:The type IA osteogenesis imperfecta (OI) phenotype is characterized by multiple fractures, blue sclerae, and minimal skeletal deformity without dentinogenesis imperfecta. The object of this study was to determine the effect of treatment with intravenous pamidronate (30 mg) every 3 months on bone density and bone histo...

journal_title：Calcified tissue international

authors： Shapiro JR,McCarthy EF,Rossiter K,Ernest K,Gelman R,Fedarko N,Santiago HT,Bober M

更新日期：2003-02-01 00:00:00

abstract：:Impact activity is an important contributor to bone accrual. Children engaging in such activity have been shown to have greater bone mineral density (BMD) than their peers. This cross-sectional study was designed to quantify the association between BMD and impact activity in pre-pubescent girls, specifically examining...

journal_title：Calcified tissue international

authors： Scerpella TA,Davenport M,Morganti CM,Kanaley JA,Johnson LM

更新日期：2003-01-01 00:00:00

abstract：:Osteoclasts are multinucleated cells that carry out bone resorption. Analysis of the direct effect of hormones on the bone-resorbing activity of human osteoclasts has been limited by difficulties in isolating these cells from the human skeleton. In this study, human osteoclasts formed from cultures of peripheral blood...

journal_title：Calcified tissue international

authors： Kudo O,Sabokbar A,Pocock A,Itonaga I,Athanasou NA

更新日期：2002-12-01 00:00:00

abstract：:Undesired bone loss around implants is considered to occur mainly because of a stress-shielding phenomenon. Bone surrounding the total knee arthroplasty (TKA) adjusts its mineral density and structure to meet new mechanical demands. Immobilization, in combination with local operative trauma to the bone and soft tissue...

journal_title：Calcified tissue international

authors： Soininvaara TA,Jurvelin JS,Miettinen HJ,Suomalainen OT,Alhava EM,Kröger PJ

更新日期：2002-12-01 00:00:00

abstract：:Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 1...

journal_title：Calcified tissue international

authors： Li X,Srivastava AK,Gu W,Masinde G,Mohan S,Baylink DJ

更新日期：2002-11-01 00:00:00

abstract：:We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...

journal_title：Calcified tissue international

authors： Kikuyama A,Fukuda K,Mori S,Okada M,Yamaguchi H,Hamanishi C

更新日期：2002-09-01 00:00:00

abstract：:Peritubular dentin (PTD) is a relatively dense mineralized tissue surrounding tooth dentin tubules, whose composition and mode of formation are still unclear. Fourier transform infrared microspectroscopic studies of the organic and mineral components of the highly developed horse PTD indicate that the peritubular matr...

journal_title：Calcified tissue international

authors： Magne D,Guicheux J,Weiss P,Pilet P,Daculsi G

更新日期：2002-08-01 00:00:00

abstract：:Racial differences in bone mineral density (BMD) appear to account in part for racial differences in the incidence of osteoporosis and fractures. We previously reported that the greater BMD in adult blacks compared with whites is associated with a higher serum 17 beta-estradiol and greater secretion of growth hormone ...

journal_title：Calcified tissue international

authors： Wright NM,Papadea N,Veldhuis JD,Bell NH

更新日期：2002-03-01 00:00:00

abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...

journal_title：Calcified tissue international

authors： Mizuguchi M,Fujisawa R,Nara M,Nitta K,Kawano K

更新日期：2001-12-01 00:00:00

abstract：:Interleukin (IL)-6 is a bone-resorbing cytokine that acts primarily on osteoclast progenitors to stimulate both proliferation and differentiation. Glucocorticoids (GC) down-regulate IL-6 synthesis in different cell types, including osteoblasts. Given the fact that bone remodeling is a tightly controlled process, it is...

journal_title：Calcified tissue international

authors： Dovio A,Masera RG,Sartori ML,Racca S,Angeli A

更新日期：2001-11-01 00:00:00

abstract：:In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis...

journal_title：Calcified tissue international

authors： Gennari L,Brandi ML

更新日期：2001-10-01 00:00:00

abstract：:Limited information is available on the effect of bisphosphonates in men receiving corticosteroid therapy. We studied 184 men among the patients enrolled in two, double-blind, placebo-controlled, 1-year studies with similar protocols. The studies evaluated the effects of risedronate in patients beginning corticosteroi...

journal_title：Calcified tissue international

authors： Reid DM,Adami S,Devogelaer JP,Chines AA

更新日期：2001-10-01 00:00:00

abstract：:The effect of zinc on in vitro deoxyribonucleic acid (DNA) synthesis activity in the femoral-diaphyseal and metaphyseal tissues of newborn rats was investigated to determine a role of zinc in bone growth. In vitro DNA synthesis was assayed in a reaction mixture containing the 100 g centrifugation supernatant, which in...

journal_title：Calcified tissue international

authors： Ma ZJ,Yamaguchi M

更新日期：2001-09-01 00:00:00

abstract：:Recent studies have reported that bisphosphonates reduce fracture incidence and improve bone density in children with osteogenesis imperfecta (OI). However, questions still persist concerning the effect of these drugs on bone properties such as ultrastructure and quality, particularly in the growing patient. To addres...

journal_title：Calcified tissue international

authors： Camacho NP,Raggio CL,Doty SB,Root L,Zraick V,Ilg WA,Toledano TR,Boskey AL

更新日期：2001-08-01 00:00:00

abstract：:The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...

journal_title：Calcified tissue international

authors： Siamopoulou A,Challa A,Kapoglou P,Cholevas V,Mavridis AK,Lapatsanis PD

更新日期：2001-07-01 00:00:00